ChatDoE is Culture Biosciences’ AI-powered Design of Experiments tool, built directly into Console. It lets scientists go from an experiment idea to a statistically rigorous design in minutes, using plain English instead of complex statistical software.
Key capabilities of ChatDoE:
Conversational interface: Describe experimental goals in natural language; ChatDoE asks clarifying questions and recommends appropriate designs.
Grounded in Statistics: Designs are generated by validated statistical libraries (pyDOE). Supports Central Composite Design (CCD), Box-Behnken, Plackett-Burman, Definitive Screening, D-Optimal, and Latin Hypercube designs.
Built-in power analysis: Automatically calculates minimum detectable effect (MDE) so scientists understand exactly what each design can detect.
Intelligent design comparison: Generates multiple design options, explains trade-offs.
Bioprocess-aware: Understands industry conventions like default CVs for IgG vs. viral vector processes, blocking for bay constraints, and common design patterns from “A DOE Handbook” by Coleman and Gunter.
How It Works
Log into your Console account
Go to 'Stratyx' page
Click on 'Advanced Tools' and Select 'ChatDoE'
Describe your experiment. Tell ChatDoE your bioprocess objective, factors, and run budget. It asks targeted clarifying questions about noise, blocking, and design goals.
Receive your designs. ChatDoE evaluates multiple options, generates up to three candidate designs in parallel, and presents its top recommendation with clear tradeoff explanations.
Understand and execute. Every design includes a run-by-run table with actual factor values and a power summary showing the minimum detectable effect for each model term. These will help define your study.
Iterate your design. You can continue to iterate your design by asking ChatDoE to adjust your design in various ways including blocking, increase or decrease run budget, and adding or removing parameters. If you would like to see other designs you can do so using the designs that are already provided or ask ChatDoE to use any of the 8 designs that are preloaded.